Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3
作者： C. Andrew Stewart , Giorgio Trinchieri
DOI: 10.1007/978-1-4419-7219-4_4
关键词:
摘要: The innate and immunologic arms of host resistance to pathogenic infections use distinct patterns cytokine production direct appropriate tissue responses. This chapter discusses how this “Immunological Switch” is coordinated by T helper cell lineages IL-10 STAT3 signaling controls the inflammatory response. A particular emphasis given role in tumor-associated immunosuppression, where functional inhibition either molecule results acquiescence proinflammatory anti-tumor Th1 type immune
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