Diabetes mellitus: The epidemic of the century

摘要: The epidemic nature of diabetes mellitus in different regions is reviewed. Middle East and North Africa region has the highest prevalence adults (10.9%) whereas, Western Pacific number diagnosed with countries (37.5%). Different classes mellitus, type 1, 2, gestational other types are compared terms diagnostic criteria, etiology genetics. molecular genetics received extensive attention recent years by many prominent investigators research groups biomedical field. A large array mutations single nucleotide polymorphisms genes that play a role various steps pathways involved glucose metabolism development, control function pancreatic cells at levels major advances understanding relation to comparison previous this field briefly reviewed here. Despite accumulation data cellular levels, mechanism development complications still not fully understood. Definitely, more needed will eventually reflect on ultimate objective improve diagnoses, therapy minimize chance chronic development.