Peptides in the gastrointestinal tract in human immunodeficiency virus infection
作者： Keith A Sharkey , Lloyd R Sutherland , Joseph S Davison , Henk Zwiers , M John Gill
DOI: 10.1016/0016-5085(92)91090-Q
关键词:
摘要: The presence of immunoreactivity to the neuronal phosphoprotein B-50 and peptides bombesin, calcitonin gene-related peptide, galanin, neurotensin, neuropeptide Y, somatostatin, substance P, vasoactive intestinal polypeptide was examined in biopsy specimens from duodenum rectum human immunodeficiency virus (HIV)-seropositive HIV-seronegative male homosexual patients. distribution correlated with HIV serology, number CD4+ lymphocytes, culture. There a very low incidence enteric pathogens both groups It found that HIV-seropositive patients had greater abnormal patterns (reduced intensity and/or density innervation) nerves enteroendocrine cells than A reduction P significantly reduced lymphocyte count status; similar trend also seen for somatostatin polypeptide. Using as marker, it altered rectal nerves. findings this study suggest some clinical symptoms associated infection may be caused by specific enteropathy influences nerve cell function altering peptide immunoreactivity.
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