Novel iridium/rhodium anti-cancer compounds

作者: Abraha Habtemariam , Peter John Sadler , Zhe Liu , Ana Maria Pizarro , Joan Josep Soldevila

DOI:

关键词:

摘要: The present invention relates to novel iridium and/or rhodium containing complexes for use as a cytotoxic, such an anti-cancer agent. There is also provided method of preparing said compounds.

参考文章(15)
Venkata A. Kallepalli, Robert E. Maleczka, Milton R. Smith, Edith Onyeozili, Process for producing oxazole, imidazole, pyrrazole boryl compounds ,(2007)
Michael J. Fazio, Ramaiah Muthyala, Douglas K. Pollock, Muthiah N. Inbaskaran, William J. Kruper, William A. Fordyce, Functionalized polyamine chelants and rhodium complexes thereof for conjugation to antibodies ,(1988)
Mhd. Ali Nazif, Jan-Amadé Bangert, Ingo Ott, Ronald Gust, Raphael Stoll, William S. Sheldrick, Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding. Journal of Inorganic Biochemistry. ,vol. 103, pp. 1405- 1414 ,(2009) , 10.1016/J.JINORGBIO.2009.08.003
Michael A. Scharwitz, Ingo Ott, Yvonne Geldmacher, Ronald Gust, William S. Sheldrick, Cytotoxic half-sandwich rhodium(III) complexes: Polypyridyl ligand influence on their DNA binding properties and cellular uptake Journal of Organometallic Chemistry. ,vol. 693, pp. 2299- 2309 ,(2008) , 10.1016/J.JORGANCHEM.2008.04.002
Stefan Wirth, Christoph J. Rohbogner, Marcin Cieslak, Julia Kazmierczak-Baranska, Stefan Donevski, Barbara Nawrot, Ingo-Peter Lorenz, Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity Journal of Biological Inorganic Chemistry. ,vol. 15, pp. 429- 440 ,(2010) , 10.1007/S00775-009-0615-4
R. M. C. Dawson, Data for Biochemical Research ,(1969)
Lisa S. Park-Gehrke, John Freudenthal, Werner Kaminsky, Antonio G. DiPasquale, James M. Mayer, Synthesis and oxidation of Cp*IrIII compounds: functionalization of a Cp* methyl group Dalton Transactions. pp. 1972- 1983 ,(2009) , 10.1039/B820839E
Michaël Gras, Bruno Therrien, Georg Süss-Fink, Angela Casini, Fabio Edafe, Paul J. Dyson, Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N -chelating ligand Journal of Organometallic Chemistry. ,vol. 695, pp. 1119- 1125 ,(2010) , 10.1016/J.JORGANCHEM.2010.01.020
Youcef Boutadla, Omar Al-Duaij, David L. Davies, Gerald A. Griffith, Kuldip Singh, Mechanistic Study of Acetate-Assisted C−H Activation of 2-Substituted Pyridines with [MCl2Cp*]2 (M = Rh, Ir) and [RuCl2(p-cymene)]2 Organometallics. ,vol. 28, pp. 433- 440 ,(2009) , 10.1021/OM800909W