Differential Sperm Motility Mediates the Sex Ratio Drive Shaping Mouse Sex Chromosome Evolution

摘要: Summary The mouse sex chromosomes exhibit an extraordinary level of copy number amplification postmeiotically expressed genes [ 1 , 2 ], driven by “arms race” (genomic conflict) between the X and Y over control offspring ratio. sex-linked ampliconic transcriptional regulators Slx Sly 3 4 5 6 7 ] have opposing effects on global transcription levels in haploid spermatids via regulation postmeiotic chromatin (PMSC) 8 9 10 11 Partial deletions chromosome (Yq) that reduce lead to overexpression either a distorted ratio favor females (smaller deletions) or sterility (larger 12 13 14 15 16 ]. Despite large body work studying role regulating spermatogenesis (recent reviews 17 18 19 20 ]), most studies do not address differential fertility X- and Y-bearing cells. Hence, this study, we concentrate identifying physiological differences sperm from Yq-deleted males affect their relative fertilizing ability consequently skewing. We show X- these motility morphology but are equally able penetrate cumulus fertilize egg once at site of fertilization. altered is thus deduced be proximate cause skew. This represents first demonstration specific difference function associated with