COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AUTOIMMUNE DISEASES

摘要: Disclosed are compositions and methods for detecting, isolating, and/or characterizing a T cell or autoantibody associated with type I diabetes. The composition comprise the use of hybrid insulin peptide having an N-terminal amino acid sequence taken from human C-terminal secretory granule protein that joined through bond to form autoimmune antigen. isolating characterization step further includes performing immunoassay proliferation assay disclosed peptides, where preferably, is ELISPOT assay.