Applications of Mass Spectrometry in Drug Development Science

作者: Ulrike Leurs , Ulrik H. Mistarz , Kasper D. Rand

DOI: 10.1007/978-1-4939-4029-5_7

关键词:

摘要: Mass spectrometry (MS) offers the capability to identify, characterize and quantify a target molecule in complex sample matrix has developed into premier analytical tool drug development science. Through specific MS-based workflows including customized preparation, coupling liquid chromatography different ionization principles, both qualitative quantitative analysis of small large compounds can be achieved at an unprecedented sensitivity.

参考文章(47)
Alan G. Marshall, Christopher L. Hendrickson, Stone D.-H. Shi, Scaling MS plateaus with high-resolution FT-ICRMS. Analytical Chemistry. ,vol. 74, ,(2002) , 10.1021/AC022010J
Robert E. Ardrey, Liquid Chromatography – Mass Spectrometry: An Introduction Analytical Techniques in the Sciences. ,(2003) , 10.1002/0470867299
Klaus Th Wanner, Georg Hofner, Mass spectrometry in medicinal chemistry : Wiley-VCH ;Chichester :John Wiley [distributor],. ,(2007)
Li Tao, Michael Ackerman, Wei Wu, Peiran Liu, Reb Russell, Characterization of Impurities and Degradants in Protein Therapeutics by Mass Spectrometry Characterization of Impurities and Degradants Using Mass Spectrometry. pp. 391- 426 ,(2011) , 10.1002/9780470921371.CH12
P. Roepstorff, J. Fohlman, Letter to the editors Biological Mass Spectrometry. ,vol. 11, pp. 601- 601 ,(1984) , 10.1002/BMS.1200111109
Jarrod A. Marto, Joshua J. Coon, John Edward Philip Syka, Donald F. Hunt, Electron transfer dissociation for biopolymer sequence analysis ,(2005)
Deepangi Pandit, Steven J. Tuske, Stephen J Coales, Sook Yen E, Anita Liu, Jessica E. Lee, Jeffrey A. Morrow, Jennifer F. Nemeth, Yoshitomo Hamuro, Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking Journal of Molecular Recognition. ,vol. 25, pp. 114- 124 ,(2012) , 10.1002/JMR.1169