Pharmacological modulation by celecoxib of cachexia associated with experimental arthritis and atherosclerosis in rabbits

摘要: BACKGROUND AND PURPOSE Non-steroidal anti-inflammatory drugs improve inflammatory cachexia in several conditions. Thus, we have explored inhibition of cyclooxygenase-2 (COX-2) an experimental model rheumatoid rabbits. EXPERIMENTAL APPROACH Chronic arthritis was induced immunized rabbits by repeated intra-articular injections ovalbumin. To increase the degree systemic inflammation and also to induce atherosclerotic lesions, animals were fed a hyperlipidaemic diet (2% cholesterol 6% peanut oil) given endothelial injury femoral artery. Rabbits randomized receive COX-2 inhibitor celecoxib (10 mg·kg−1·day−1) or no treatment. After 4 weeks, sera, peripheral mononuclear cells vessel specimens collected. KEY RESULTS Inhibition modulated response increased total triglyceride levels. Celecoxib minimized weight loss prevented serum albumin fall. At vascular level, reduced protein arterial wall, but did not modify size macrophage infiltration lesions nor percentage with spontaneous aortic plaques. CONCLUSIONS IMPLICATIONS Our animal severe cachexia, comparable that persistently active arthritis. The improves this state, suggesting COX products play important role its development, without affecting development progression lesions. Overall, these results suggest might be considered as new therapeutic tool for treatment cachexia.