The Glomerulus: Mechanisms and Patterns of Injury

摘要: So far, knowledge of the mechanisms glomerular toxicity drugs and chemicals was largely descriptive, mainly reflecting associated pathology, or biochemical functional consequences exposing cells to a given toxic molecule. However, more recently understanding has expanded, orienting toward new cell surface molecules, soluble mediators, novel injury. Moreover, studies drug had allowed us better define structural determinants filtration identify pathways abnormal permeability macromolecules that may cause progressive renal disease.