Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii.

摘要: Summary Most intracellular parasites employ sophisticated mechanisms to direct biogenesis of a vacuolar replicative niche that circumvents default maturation through the endolysosomal cascade. However, this is not case Q fever bacterium, Coxiella burnetii. This hardy, obligate pathogen has evolved only survive, but thrive, in harshest compartments: phagolysosome. Following internalization, nascent phagosome ultimately develops into large and spacious parasitophorous vacuole (PV) acquires lysosomal characteristics such as acidic pH, acid hydrolases cationic peptides, defences designed rid host intruders. transit environment initially stalled, process apparently modulated by interactions with autophagic pathway. actively participates its PV synthesizing proteins mediate stalling, interactions, development maintenance mature vacuole. Among potential mediating these processes deployment type IV secretion system deliver effector cytosol. Here we summarize our current understanding cellular events occur during parasitism cells Coxiella.