Direct analysis of tetrahydrobiopterin in cerebrospinal fluid by high-performance liquid chromatography with redox electrochemistry: Prevention of autoxidation during storage and analysis
作者： D.W. Howells , K. Hyland
DOI: 10.1016/0009-8981(87)90081-7
关键词:
摘要: Abstract Measurement of tetrahydrobiopterin in cerebrospinal fluid requires careful handling samples during storage and analysis. Addition dithioerythritol deoxygenation the mobile phase with helium prevents breakdown chromatography. Tetrahydrobiopterin is unstable at room temperature, 100% being lost within 3.5 h, this does not generate equivalent quantities dihydrobiopterin biopterin. diethylenetriaminepenta-acetic acid to for 6 mth −70°C up 5 h 4°C. At temperature
elsevier.com
sci-hub.se 参考文章(15)
Sheldon Milstien, George K. Summer, Seymour Kaufman, Hyperphenylalaninemia Due to Dihydropteridine Reductase Deficiency: Diagnosis by Measurement of Oxidized and Reduced Pterins in Urine Pediatrics. ,vol. 65, pp. 806- 810 ,(1980)
Theodore A. Hare, James H. Wood, Pathological Neurochemistry of Cerebrospinal Fluid Springer, Boston, MA. pp. 421- 447 ,(1985) , 10.1007/978-1-4757-0797-7_16
Y Matsubara, J A Heininger, Y Y Lin, Improved diagnosis of classical vs atypical phenylketonuria by liquid chromatography. Clinical Chemistry. ,vol. 30, pp. 278- 280 ,(1984) , 10.1093/CLINCHEM/30.2.278
D.W. Howells, I. Smith, K. Hyland, Estimation of tetrahydrobiopterin and other pterins in cerebrospinal fluid using reversed-phase high-performance liquid chromatography with electrochemical and fluorescence detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 381, pp. 285- 294 ,(1986) , 10.1016/S0378-4347(00)83594-X
Barry Halliwell, John M.C. Gutteridge, Oxygen radicals and the nervous system Trends in Neurosciences. ,vol. 8, pp. 22- 26 ,(1985) , 10.1016/0166-2236(85)90010-4
K. Hyland, Estimation of tetrahydro, dihydro and fully oxidised pterins by high-performance liquid chromatography using sequential electrochemical and fluorometric detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 343, pp. 35- 41 ,(1985) , 10.1016/S0378-4347(00)84565-X
H. Hayakawa, K. Narisawa, N. Arai, K. Tada, N. Matsuo, T. Tanaka, K. Naritomi, Differential diagnosis of variant forms of hyperphenylalaninaemia by urinary pterins. Journal of Inherited Metabolic Disease. ,vol. 6, pp. 123- 124 ,(1983) , 10.1007/BF01800743
A C Williams, R A Levine, T N Chase, W Lovenberg, D B Calne, CFS hydroxylase cofactor levels in some neurological diseases. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 43, pp. 735- 738 ,(1980) , 10.1136/JNNP.43.8.735
Jon C. Nixon, Ching-Lun Lee, Sheldon Milstien†, Seymour Kaufman, Klaus Bartholomé, Neopterin and Biopterin Levels in Patients with Atypical Forms of Phenylketonuria Journal of Neurochemistry. ,vol. 35, pp. 898- 904 ,(1980) , 10.1111/J.1471-4159.1980.TB07088.X
H Deckmyn, Paolo Gresele, J Arnout, A Todisco, J Vermylen, Prolonging prostacyclin production by nafazatrom or dipyridamole The Lancet. ,vol. 2, pp. 410- 411 ,(1984) , 10.1016/S0140-6736(84)90582-8