Population Structure Can Inflate SNP-Based Heritability Estimates
作者： Sharon R. Browning , Brian L. Browning
DOI: 10.1016/J.AJHG.2011.05.025
关键词:
摘要: To the Editor: Recently, Lee et al.1 presented a method to estimate proportion of phenotypic variation explained by common SNPs for case-control phenotypes. This extends work Yang et al.2 estimating that can be quantitative traits. found 45% in height Australian individuals European descent SNPs. et al. showed high (22%–38%) liability Crohn disease, bipolar disorder, and type 1 diabetes Wellcome Trust Case-Control Consortium (WTCCC) data SNPs.1
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