Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons

摘要: Precise synaptogenesis is crucial to brain development, and depends on the ability of specific partner cells locate communicate with one another. Dynamic properties axonal filopodia during synaptic targeting are well documented, but cytomorphological dynamics postsynaptic have received less attention. In Drosophila embryos, muscle bear numerous ('myopodia') motoneuron targeting. Here we show that myopodia actin-filled microprocesses, which progressively clustered at site innervation while intermingling presynaptic filopodia. prospero mutants, severe delays in axon outgrowth from CNS, were present initially clustering behavior was not observed, demonstrating innervating axons. Thus, capable intimate interaction We propose that, by contributing direct long-distance cellular communication, they dynamically involved matchmaking.