Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation.

作者: Massimiliano Magro , Giorgio Cozza , Simone Molinari , Andrea Venerando , Davide Baratella

DOI: 10.1016/J.IJBIOMAC.2020.07.295

关键词:

摘要: Abstract The knowledge of protein-nanoparticle interplay is crucial importance to predict the fate nanomaterials in biological environments. Indeed, protein corona on responsible for physiological response organism, influencing cell processes, from transport accumulation and toxicity. Herein, a comparison using four different proteins reveals existence patterned regions carboxylic groups acting as recognition sites naked iron oxide nanoparticles. Readily interacting display distinctive surface distribution groups, recalling geometric shape an ellipse. This morphologically complementary nanoparticles curvature compatible with topography exposed FeIII laying nanomaterial surface. site, absent non-interacting proteins, promotes nanoparticle harboring allows formation functional coronas. present work envisages possibility predicting composition properties metal

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