Biochemical and Physiological Studies of the Beta-Adrenoceptor and the D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland: A Review

摘要: The intermediate lobe (IL) of the rat pituitary gland responds to catecholamines. Catecholamines interacting with β-adrenoceptor stimulate adenylate cyclase activity, enhance cyclic AMP formation and thereby trigger release α-melanocyte-stimulating hormone (α-MSH). a D-2 dopamine receptor (in classification schema Kebabian Calne) diminish activity decrease capacity IL cells synthesize AMP. Dopaminergic agonists also inhibit α-MSH from cells. homogeneity facilitates biochemical investigations this tissue.