Relationship Between Baseline Glycemic Control and Cognitive Function in Individuals With Type 2 Diabetes and Other Cardiovascular Risk Factors: The Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial

摘要: OBJECTIVE—Diabetes is associated with cognitive decline and dementia. However, the relationship between degree of hyperglycemia status remains unclear. This was explored using baseline measures collected in ongoing Memory Diabetes (MIND) substudy Action to Control Cardiovascular Risk (ACCORD) trial. RESEARCH DESIGN AND METHODS—The A1C fasting plasma glucose (FPG) levels performance on four tests assessed, adjusting for age other determinants status. The were Digit Symbol Substitution Test (DSST), Mini Mental Status Examination (MMSE), Rey Auditory Verbal Learning Test, Stroop Test. RESULTS—A statistically significant age-adjusted association observed level score all tests. Specifically, a 1% higher value 1.75-point lower DSST (95% CI −1.22 −2.28; P < 0.0001), 0.20-point MMSE (−0.11 −0.28; 0.11-point memory (−0.02 −0.19, = 0.0142), worse (i.e., 0.75 s more) (1.31–0.19, 0.0094). persisted multiple linear regression models. FPG not test performance. CONCLUSIONS—Higher are function individuals diabetes. effect lowering will be determined by ACCORD-MIND trial.