Myocardial deformation imaging unmasks subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients.

摘要: Patients infected by the human immunodeficiency virus (HIV) and receiving highly active antiretroviral therapy have a higher incidence of cardiovascular disease than healthy subjects, but little is known about cardiac function in asymptomatic treatment-naive patients. We sought to study HIV-infected, studied 41 HIV-infected patients 20 age- sex-matched controls. with symptoms, history or NT-proBNP >100 pg/mL were excluded. addressed using standard echocardiography along tissue Doppler (TDI) measurements, including strain/strain rate assessment. Standard echocardiographic parameters did not differ between groups, except for transmitral E wave velocity (64.8 ± 14 cm/s HIV vs 76.1 ± 10 cm/s controls, p = 0.002). In contrast, TDI mitral tricuspid annulus s all measurements significantly lower patients: lateral, 10.2 ± 2.4/11.3 ± 0.7, p = 0.011; septal, 8.1 ± 1.6/8.7 ± 0.8, p = 0.045; tricuspid, 13.4 ± 2.3/14.9 ± 1.3, p = 0.002; rate, septal (strain/strain 15.1 ± 5.7/−0.9 ± 0.3, 25.3 ± 1.7/−1.9 ± 0.2, p < 0.001), anterior (16.7 ± 3/−1.0 ± 0.1, 26.7 ± 1.7/−1.9 ± 0.2, lateral (16.0 ± 6/−1.0 ± 0.1, 27.5 ± 1.8/−2.2 ± 0.3, p < 0.001) posterior (15.2 ± 5.8/−1.0 ± 0.2, 26.2 ± 1.8/−2.2 ± 0.3, left ventricular wall. infection itself accompanied subclinical systolic dysfunction, apparent that can be unmasked though sensitive techniques.