Immune surveillance of EBV-infected B cells and the development of non-Hodgkin lymphomas in immunocompromised patients

摘要: After infection with the Epstein – Barr virus, a common gammaherpes virus which infects and persists in B cells, an equilibrium is established newly infected differentiating cells are controlled by cytotoxic T cell (CTL) responses. Disturbance of this equilibrium, can occur immunocompromised situations, lead to uncontrolled lymphoproliferation subsequent development non-Hodgkin Lymphomas (NHL). Here, we review role immunesurveillance EBV-infected two situations where altered because immunodeficiencies, transplantation recipients HIV infection, EBV-mediated NHL. In transplant recipients, immunosuppression prior during lack results proliferation would normally be CTL Interestingly, both deregulation normal biology reduction immunity play dev...