Assessing intracranial vascular compliance using dynamic arterial spin labeling

摘要: Vascular compliance (VC) is an important marker for a number of cardiovascular diseases and dementia, which typically assessed in the central peripheral arteries indirectly by quantifying pulse wave velocity (PWV), and/or pressure waveform. To date, very few methods are available quantification intracranial VC. In present study, novel MRI technique in-vivo assessment VC was introduced, where dynamic arterial spin labeling (ASL) scans were synchronized with systolic diastolic phases cardiac cycle. defined as ratio change cerebral blood volume (ΔCBV) (ΔBP). Intracranial different vascular components using proposed ASL method. Our results show that mainly occurs large arteries, gradually decreases small arterioles. The comparison between young elderly subjects shows aging accompanied reduction VC, good agreement literature. Furthermore, positive association perfusion measured pseudo-continuous 3D GRASE observed independent effects, suggesting loss associated decline perfusion. Finally, significant correlation (aortic arch) ungated phase-contrast 1D projection PWV technique. method offers promising approach assessing range dementia.