Racial-ethnic disparities in empirically-derived subtypes of subclinical psychosis among a U.S. sample of youths.

摘要: Abstract Introduction Racial-ethnic minority status is a consistent risk factor for schizophrenia, with associations extending to bipolar disorder and subthreshold psychotic experiences. However, few epidemiologic studies have been conducted in the U.S., evidence inconsistent. Furthermore, no U.S. of youths directly investigated phenomenological overlap between schizophrenia disorder. We aimed do so at level Philadelphia Neurodevelopmental Cohort. Methods Participants included 6533 individuals, age 11–21 years, from community healthcare network. Latent class analysis was used form subtypes sub-psychosis based on 12 attenuated positive items 7 mania without duration criteria. Associations race-ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, “other”) subtype were estimated using latent regression. Results Four classes identified: Sub-positive Only (13.4%), Mania (15.5%), Both (9.1%), Neither (62.0%). Minority participants generally more likely than whites belong one three compared class. Hispanics blacks remained after adjustment age, sex, maternal education, restriction significant physical health conditions. disparities greater magnitude two characterized by sub-positive symptoms, Both, This pattern statistically among blacks. Conclusions found racial-ethnic empirically-derived psychosis, broadly defined, youths. Further research needed determine whether these persist clinical adulthood.