Regulation of fc receptor endocytic trafficking by ubiquitination.

摘要: Most immune cells, particularly phagocytes, express various receptors for the Fc-portion of different immunoglobulin isotypes (Fc receptors, FcRs). By binding to antibody, they provide a link between adaptive system and powerful effector functions triggered by innate cells such as mast neutrophils, macrophages, NK cells. Upon ligation complexes, downstream signalling pathways initiated are quite similar FcR classes leading secretion preformed de novo synthesized pro-inflammatory mediators. engagement also promotes negative signals through combined action several molecules that limit extent duration positive signalling. To this regard, ligand-induced ubiquitination Fc IgE (FceR) IgG (FcγR) has become recognized key modification generates internalization and/or delivery engaged receptor complexes lysosomes or cytoplasmic proteasomes degradation, providing negative-feedback regulation activity. In review, we discuss recent advances in our understanding molecular mechanisms ensure clearance Fce Fcγ from cell surface with an emphasis given cooperation ubiquitin pathway endosomal adaptors including sorting complex required transport (ESCRT) controlling along endocytic compartments.