Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
作者： K.S.C.R. dos Santos , J.F.J. Coelho , P. Ferreira , I. Pinto , S.G. Lorenzetti
DOI: 10.1016/J.IJPHARM.2005.11.019
关键词:
摘要: Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate chemical initiator. Evidence for the vinyl monomers was obtained FTIR DMTA. Swelling degree, cytotoxicity, thrombogenicity haemolytic activity these evaluated. Chitosan-graft-AA-graft-HEMA showed best matrix than chitosan-graft-AA because it retains good swelling properties, but content in HEMA has improved cytocompatibility, hemocompatibility thrombogenic character.
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