Biocompatible microemulsions for fabrication of glyceryl monostearate solid lipid nanoparticles (SLN) of tretinoin.
作者： Kumar A. Shah , Medha D. Joshi , Vandana B. Patravale
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摘要: The objective of the present investigation was to fabricate glyceryl monostearate SLN by employing a biocompatible microemulsion as template. Biocompatible excipients such Tween 20 (as surfactant) and Transcutol P (a cosourfactant) (at different K(m) ratios) were selected for fabrication microemulsions. Pseudo-ternary phase diagrams plotted identify area existence. Glyceryl fabricated dispersing (maintained at 65 degrees C) into cold water 2-3 C). particle size determined photon correlation spectroscopy. Tretinoin, lipophilic anti-acne agent incorporated model drug. encapsulation efficiency tretinoin in using Nanosep ultrafilteration device lipid loads viz. 1%, 1.5% 2%. from template exhibited average 175 nm polydispersity index 0.833. Tretinoin could be successfully ranged 37-48% loads.
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