Ionophores Alter Hepatic Concentrations of Intermediary Carbohydrate Metabolites in Steers

摘要: The effects of ionophores on liver weight and function were determined in finishing steers (n = 24; avg 440 kg). Steers group-fed one three treatments (control, lasalocid or monensin at 33 mg/kg feed) for 46 d prior to slaughter. Three days slaughter, blood was collected the determination serum Ca Mg. At removed, weighed, sampled, frozen liquid nitrogen subsequently analyzed concentrations carbohydrate metabolites minerals. Liver (5.9 kg) unaffected by treatment. Serum hepatic Mg not affected ionophore Hepatic glycogen levels fed Fructose 1,6-bisphosphate 21% lower (P less than .10) tissue ionophores, whereas dihydroxyacetone phosphate 15 37% greater .20) .10). Glyceraldehyde 3-phosphate elevated more extensively with increases 72 .05) 132% .001), respectively, over controls. Glycerol 12% (NS) these ionophores. pyruvate 12 36% .17) lasalocid. 2,6-bisphosphate 25% .25) from control steers. Other metabolism altered appreciably. Changes intermediary suggest alterations favoring gluconeogenesis