Protein binding of N-2-mercaptoethyl-1,3-diaminopropane via mixed disulfide formation after oral administration of WR 2721.

摘要: Earlier studies have shown that WR 2721 [H2N-(CH2)3-NH(CH2)2SPO3H2] is converted to its free thiol form, N-2-mercaptoethyl-1,3-diaminopropane (MDP), at the acidic pH of stomach. MDP a radioprotective compound and mucolytic agent capable decreasing sputum viscosity in lungs patients with cystic fibrosis. Conversion corresponding sulfonic acid (MDP-SO3H) permits quantitative determination these compounds physiological fluids by use an automatic amino analyzer. After oral administration human rabbits it form drug associates plasma proteins mixed disulfide linkage. The serve as depot reservoir for potential exchange tissues. When incubated whole or purified mucin solutions vitro, decreased reduction accessible bonds molecule was subsequently found association molecule. via linkage has important implications development optimal dose regimens patients.