Capillary gas chromatographic determination of epomediol in human plasma and urine using a rapid solid-phase extraction.
作者： Maria Angela Girometta , Loredana Loschi , Paolo Ventura , Sergio Canali , Claudio Giachetti
关键词:
摘要: A simple and precise method for the quantitation of epomediol in human plasma urine is described. Each biological sample added with internal standard applied directly to an Extrelut-1 solid-phase column. After absorption column eluted chloroform eluate evaporated dryness. The residue, reconstituted ethanol, analysed by capillary gas chromatography. No interferences from possible metabolites or endogenous constituents can be noted. has been pharmacokinetic studies: results a subacute administration volunteers are presented.
sci-hub.se 参考文章(5)
Paolo Ventura, Sandro Serafini, Roberto Pria, Biotransformation of epomediol. III. Gas chromatographic analysis of rat plasma, bile, urine and faeces. Journal of Chromatography A. ,vol. 245, pp. 350- 354 ,(1982) , 10.1016/S0021-9673(00)88022-X
Giuseppina Barrera, Maurizio Parola, Effect of epomediol on the ATPase and adenylate cyclase activities in plasmamembranes isolated from rat liver Pharmacological Research Communications. ,vol. 16, pp. 1133- 1140 ,(1984) , 10.1016/S0031-6989(84)80078-8
Wilfred J Westlake, None, Use of Confidence Intervals in Analysis of Comparative Bioavailability Trials Journal of Pharmaceutical Sciences. ,vol. 61, pp. 1340- 1341 ,(1972) , 10.1002/JPS.2600610845
Jose Ferreira de Carvalho, N. R. Draper, H. Smith, Applied regression analysis 2nd ed. Journal of the American Statistical Association. ,vol. 76, pp. 1012- ,(1981) , 10.2307/2287608
Paolo Ventura, Antonio Selva, Biotransformation of epomediol. I--Isolation and identification of main metabolites in the rat. Journal of Mass Spectrometry. ,vol. 9, pp. 18- 21 ,(1982) , 10.1002/BMS.1200090105