Tuning flux: autophagy as a target of heart disease therapy.

作者: Min Xie , Cyndi R Morales , Sergio Lavandero , Joseph A Hill

DOI: 10.1097/HCO.0B013E328345980A

关键词:

摘要: Purpose of reviewDespite maximum medical and mechanical support therapy, heart failure remains a relentlessly progressive disorder with substantial morbidity mortality. Autophagy, an evolutionarily conserved process cellular cannibalization, has been implicated in virtually all forms cardi

参考文章(41)
D. J. Cao, Z. V. Wang, P. K. Battiprolu, N. Jiang, C. R. Morales, Y. Kong, B. A. Rothermel, T. G. Gillette, J. A. Hill, Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 4123- 4128 ,(2011) , 10.1073/PNAS.1015081108
Dominika Nowis, Michał Mączewski, Urszula Mackiewicz, Marek Kujawa, Anna Ratajska, Mariusz R. Wieckowski, Grzegorz M. Wilczyński, Monika Malinowska, Jacek Bil, Paweł Salwa, Marek Bugajski, Cezary Wójcik, Maciej Siński, Piotr Abramczyk, Magdalena Winiarska, Anna Dąbrowska-Iwanicka, Jerzy Duszyński, Marek Jakóbisiak, Jakub Golab, Cardiotoxicity of the Anticancer Therapeutic Agent Bortezomib American Journal of Pathology. ,vol. 176, pp. 2658- 2668 ,(2010) , 10.2353/AJPATH.2010.090690
Roberta A. Gottlieb, Robert M. Mentzer, Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy Annual Review of Physiology. ,vol. 72, pp. 45- 59 ,(2010) , 10.1146/ANNUREV-PHYSIOL-021909-135757
Noboru Mizushima, Daniel J. Klionsky, Protein turnover via autophagy: implications for metabolism. Annual Review of Nutrition. ,vol. 27, pp. 19- 40 ,(2007) , 10.1146/ANNUREV.NUTR.27.061406.093749
Sawa Kostin, Lieven Pool, Albrecht Elsässer, Stefan Hein, Hannes C.A. Drexler, Eyal Arnon, Yukihiro Hayakawa, René Zimmermann, Erwin Bauer, Wolf-Peter Klövekorn, Jutta Schaper, Myocytes Die by Multiple Mechanisms in Failing Human Hearts Circulation Research. ,vol. 92, pp. 715- 724 ,(2003) , 10.1161/01.RES.0000067471.95890.5C
Guido Kroemer, Guillermo Mariño, Beth Levine, Autophagy and the Integrated Stress Response Molecular Cell. ,vol. 40, pp. 280- 293 ,(2010) , 10.1016/J.MOLCEL.2010.09.023
Michael Arad, Barry J. Maron, Joshua M. Gorham, Walter H. Johnson, J. Philip Saul, Antonio R. Perez-Atayde, Paolo Spirito, Gregory B. Wright, Ronald J. Kanter, Christine E. Seidman, J.G. Seidman, Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy The New England Journal of Medicine. ,vol. 352, pp. 362- 372 ,(2005) , 10.1056/NEJMOA033349
L. Yan, D. E. Vatner, S.-J. Kim, H. Ge, M. Masurekar, W. H. Massover, G. Yang, Y. Matsui, J. Sadoshima, S. F. Vatner, AUTOPHAGY IN CHRONICALLY ISCHEMIC MYOCARDIUM Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 13807- 13812 ,(2005) , 10.1073/PNAS.0506843102
Martin G. St. John Sutton, Ted Plappert, Hind Rahmouni, Assessment of Left Ventricular Systolic Function by Echocardiography Heart Failure Clinics. ,vol. 5, pp. 177- 190 ,(2009) , 10.1016/J.HFC.2008.11.010
Kazuhiko NISHIGAKI, Shinya MINATOGUCHI, Koshi GOTO, Hisayoshi FUJIWARA, Mieko SAIJO, Genzou TAKEMURA, Masahiko KODA, Hideshi OKADA, Shusaku MIYATA, Yasushi OHNO, Masanori KAWASAKI, Kunihiko TSUCHIYA, Cardiomyopathy with prominent autophagic degeneration, accompanied by an elevated plasma brain natriuretic peptide level despite the lack of overt heart failure. Internal Medicine. ,vol. 43, pp. 700- 703 ,(2004) , 10.2169/INTERNALMEDICINE.43.700