Lymphatic Follicles and Immunologic Cell Reaction in Human Jejunal Mucosa Obtained by Peroral Biopsy in Infectious Hepatitis

摘要: The concept that the lymphoid tissue of gastrointestinal tract is primarily involved in immune defense mechanism has been repeatedly maintained by several investigators [1, 2]. Activation intestinal lymphocytes to large pyroninophilic cells observed cases where lymphocytes, after crossing basement membrane, have penetrated between or into covering epithelium villi [3, 4, 5, 6]. Such lymphatic transformation interpreted as an immunological reaction, but most overwhelming evidence function was provided studies Good and co-workers [7, 8, 9, 10], showing Peyer’s-patch-type represents mammalian counterpart bursa Fabricii birds. On other hand, it shown plasma mucosa constitute major source gamma-A immunoglobulins [11] gamma-M are significantly increased infectious hepatitis [12], which considered a generalized disease [13, 14]. Because jejunal occasionally shows partial villous atrophy frequently marked cellular infiltration within tunica propria [15], we undertook present investigation. This study performed ascertain whether contains immunologically activated cells, determine quantity these investigate behavior follicles germinal centers duodenojejunal during course hepatitis. These findings could be related recent concepts tract.