Are there benefits to a fresh whole blood vs. packed red blood cell cardiopulmonary bypass prime on outcomes in neonatal and pediatric cardiac surgery

摘要: Techniques for pediatric cardiac surgery requiring cardiopulmonary bypass (CPB) have significantly improved over the years. The use of fresh whole blood (FWB) and pre-bypass ultrafiltration (PBUF) has been suggested as means improving perioperative postoperative outcomes. It is intent this study to show that along with PBUF will result in balanced CPB prime can offer a reduction product exposures loss several measured After institutional review board approval, retrospective was conducted on 100 patients analyze benefits FWB outcomes neonatal surgery. Data analysis included preoperative data, inotrope exposure, exposure up 12-hour period intensive care unit (ICU). three groups compared were vs. packed red cell (PRBC) prime, < 5 kg PRBC 5+ prime. Cumulative group found 62% received one operative (p .0001). majority who (64%) or more cumulative .0003). also less 64% receiving just exposure. Comparatively, 85% perioperatively postoperatively Perioperative did not differ among groups. Outcomes intraoperative death, extubation, delayed sternal closure, mediastinal reexploration statistically different. results leads specifically 5-kg population. Finally, an effective method achieving balanced, physiologic Future research would be helpful determining which specific patient populations receive greatest benefit from PBUF.