Risk of human immunodeficiency virus (HIV) transmission by blood transfusions before the implementation of HIV-1 antibody screening. The Transfusion Safety Study Group.

摘要: Little information is available regarding the risk of human immunodeficiency virus type 1 (HIV-1) infection for patients transfused before routine anti-HIV-1 screening blood donors was instituted in March 1985. A model developed estimating both proportion and number transfusion recipients San Francisco Bay area who were infected by HIV-1 during each 7 years preceding donor anti-HIV-1. The based on analysis 1) donation histories HIV-1-infected identified at regional center; 2) seroprevalence estimates homosexual bisexual men Francisco; 3) survival rates traced Transfusion Safety Study Irwin Memorial Blood Centers' Look Back Program. incidence transfusion-associated estimated to have risen rapidly from first occurrence 1978 a peak late 1982 approximately 1.1 percent per unit. decrease after coincided with implementation high-risk deferral measures. It that, overall, 2135 region alone. This suggests higher prevalence than has been generally recognized indicates need continued tracing potentially exposed recipients. data also strongly support effectiveness early education self-exclusion measures emphasize importance research development this area.