Caveolin-1 Modifies the Immunity to Pseudomonas aeruginosa

摘要: The inflammatory response to Pseudomonas aeruginosa is not properly regulated in the lungs of patients with cystic fibrosis (CF). In lung epithelium individuals wild-type CF transmembrane conductance regulator, lipid rafts containing transmembrance regulator are rapidly formed P. infection, and this closely linked resistance infection disease. We found these also contained high levels caveolin-1 thus examined sensitivity cav1 knockout (KO) mice challenge both acute chronic models. that KO had increased as represented by an mortality rate, elevated bacterial burdens recovered from spleens, responses. These findings correlated decreased ability cav1-deficient neutrophils phagocytose aeruginosa. addition, colonized much better compared controls a model indicting important contribution Cav-1 innate host immunity setting pneumonia typical CF.