Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus.

摘要: Intensity and frequency are the two main properties of sound. The non-monotonic neurons in auditory system thought to represent sound intensity. central nucleus inferior colliculus (ICC), as an important information integration system, is also involved processing intensity encoding. Although previous researchers have hinted at importance inhibitory effects on formation neurons, specific underlying synaptic mechanisms ICC still unclear. Therefore, we applied vivo whole-cell voltage-clamp technique record excitatory postsynaptic currents (EPSCs IPSCs) compared excitation inhibition membrane potential outputs. We found that neuron responses could not only be inherited from lower but created ICC. By integrating with a relatively weak IPSC, approximately 35% monotonic inputs remained In remaining cases, were reshaped into outputs, nature no-monotonic was enhanced by dominating high