Birth Cohort Effects in Multiple Sclerosis
作者： Ya-Ping Jin , Jesús De Pedro-Cuesta , Gonzalo López-Abente , Hans Link
DOI: 10.1016/S1047-2797(02)00278-8
关键词:
摘要: Abstract PURPOSE: To identify potential birth cohort effects in multiple sclerosis Sweden and particularly Stockholm county. METHODS: Data on causes of death from during 1962 to 1995 1968 county were analyzed using age-period-cohort models curvature. RESULTS: Mortality was higher than county, with stable time trends, slight period marked age effects. Cohorts born before or after a central period, 1910 through 1930, registered lower mortality. A periodic wave-form mortality pattern identified, following 5-to-6-year cycle for cohorts 1925 both outside changing longer irregular cycles 1930. CONCLUSIONS: Although methodological constraints inducing the saw-tooth cannot be excluded, these results are consistent etiologic hypotheses claiming role environmental factors sclerosis.
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