Signalling Pathways Operated by Receptor Protein Tyrosine Kinases

摘要: The first RTK discovered was the EGFR. It also receptor that provided evidence for a relationship between activating mutations (oncogenes) and cancer. About 90 genes code protein tyrosine kinases in human genome, out of which 58 are receptors (rPTK) classified into 20 subfamilies. remaining 32 non-receptor type (nrPTK). is an interesting fact mouse homologues have been identified nearly all kinases. Tyrosine phosphorylation not limited to actions transforming viruses or growth factors. regulates many other important signaling processes specified this chapter. assembly complexes depends on protein–protein interactions involve phosphorylated factor receptors. clues mechanism came from studies p47gag-crk, devoid any catalytic activity. Many phosphatases regulated by with their substrates at non-catalytic regions, docking motifs help avoid indiscriminate phosphorylations dephosphorylations. idea mitogen-activated (MAP) form stable links arose JNK2, isolated cell lysates tight association its substrate c-Jun. Later chapter presents number signal transduction pathways branch complex discusses pathway switching, transactivation, metastatic progression.