Age moderates the relationship between cortical thickness and cognitive performance

摘要: Abstract Findings from cross-sectional and longitudinal magnetic resonance imaging (MRI) studies indicate that cortical thickness declines across the adult lifespan, with regional differences in rate of decline. Global have also been found to co-vary cognitive performance. Here we examined relationships between age, mean thickness, associative recognition performance three age groups (younger, middle-aged older adults; total n = 133). Measures were obtained using a semi-automated method. Older was associated decreased memory reduction thickness. After controlling for potentially confounding effects head motion, negatively younger participants, but positively correlated participants. A similar weaker pattern evident scores on four constructs derived neuropsychological test battery. This is consistent prior findings indicating direction association reverses early later adulthood. In addition, motion independently middle-aged, not older, suggesting variance determined by multiple factors vary their relative influences age.