Clinicopathological analysis of splenic red pulp low‐grade B‐cell lymphoma

摘要: Primary splenic low-grade B-cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and lymphoma/leukemia, unclassifiable (SPLL-U). SPLL-U is a rare disease that includes subtypes leukemia-variant (HCL-v), diffuse small (SDRPL) other types are known as narrow sense (SPLL-U-NS). Notably, limited information available regarding BRAF mutation (V600E) cyclin D3 expression in SPLL-U. Therefore, we performed pathological analysis characterized features We reviewed findings 12 cases. The cases considered included two HCL-v, six SPLL-U-NS four undetermined was detected three cases, which were all SPLL-U-NS. Cases with have increased levels CD103 decreased D1 compared lacked mutation. These suggest might play significant role significance should be evaluated via genomic or transcriptional analyses large cohort patients.