A Wearable Biosensor with Biocompatible Polymers

摘要: Rapid increasing of diabetes mellitus is a significant social problem global dimensions. Although there are variety measurement technologies for self-administration, they invasive and not suitable continuous monitoring. Continuous monitoring strongly requested. On the other hand, it reported that blood glucose which incorporated by liver excreted in sweat if higher sugar level continues [1]. This indicates chronic hyperglycemia non-invasively. out skin surface useful detecting [2]. Thus, sheet-type wearable biosensor was fabricated tested. The constructed using MEMS technologies. Fig. 1 illustrates fabrication process biosensor. First, polydimethyl siloxane (PDMS) membrane deposited on dummy Si wafer, Ptand Agelectrodes were formed PDMS sputtering deposition system (e-200, Canon-Anelva Co., Japan). Then, Ag electrode electrochemically chloridized to obtain hydrogen peroxide electrode. substrate than sensing portion insulated coating with PDMS. Finally, oxidase (GOD) immobilized onto biocompatible poly (2-methacryloyloxyethyl phosphorycholine-co-2-ethylhexyl methacrylate) (PMEH). Basic characteristics sensor evaluated. photograph shown 2. flexible due characteristic its structural polymer materials. And peeling bending stress observed. as substrate, PMEH enzyme immobilization, electrodes semiconductor utilized construct 3 shows typical solution 3.0 mmol/l. A remarkable increase output enzymatic reaction response time 90% approximately 47s. current related over range 0.05-5.00 mmol/l, correlation coefficient 0.994. For future, we going develop can measure sweat, aiming at application diagnosis. wafer