Effect of phenobarbital on the absorption of inorganic and hemoglobin iron in the rat.

摘要: Previous studies have suggested that iron mucosal protein complexes, possibly related to a carrier substance, are involved in intestinal transport. Since there is evidence indicating phenobarbital induces an increase microsomal proteins and enzymes, it was postulated might affect absorption by increasing the synthesis of for iron. This investigation describes carried out rat determine effect on inorganic hemoglobin labeled with Fe 59 . In vivo SO 4 significantly increased phenobarbital-treated rats compared controls (20.4 ± 5.7 versus 9.8 4.2%; P 0.001). vitro, treatment resulted significant transfer everted duodenal gut sacs (51.3 8.8. 28.0 5.9 mμmoles; jejunal sacs. It phenobarbital-mediated substance influences Further, resulting from due, at least part, heme-splitting enzyme acitivity.