Zebrafish models for attention deficit hyperactivity disorder (ADHD).

作者: Barbara D. Fontana , Francini Franscescon , Denis B. Rosemberg , William H.J. Norton , Allan V. Kalueff

DOI: 10.1016/J.NEUBIOREV.2019.02.009

关键词:

摘要: Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental associated with inattentiveness, pathological and impulsivity. Despite the mounting human animal evidence, neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as zebrafish (Danio rerio), are becoming important tools to investigate genetic pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss etiology, existing models their limitations, emphasize advantages using ADHD. Overall, growing utility may improve our understanding facilitate drug discovery prevent or treat this disorder.

参考文章(180)
Paclt I, Gazdíková M, Koudelová J, Uhlíková P, Bauer P, Krepelová A, Biochemical markers and genetic research of ADHD. Neuro endocrinology letters. ,vol. 26, pp. 423- ,(2005)
Timothy E Wilens, James Waxmonsky, Marykate Martelon, Robert Doyle, Thomas Spencer, Jefferson B Prince, Maggie Evans, An Open Trial of Sustained Release Bupropion for Attention-Deficit/Hyperactivity Disorder in Adults with ADHD plus Substance Use Disorders Journal of ADHD & related disorders. ,vol. 1, pp. 25- 35 ,(2010)
David J Marks, Jeffrey H Newcorn, Jeffrey M Halperin, Comorbidity in Adults With Attention-Deficit Hyperactivity Disorder The Canadian Journal of Psychiatry. ,vol. 54, pp. 673- 683 ,(2009) , 10.1177/070674370905401004
Vivienne Ann Russell, Overview of Animal Models of Attention Deficit Hyperactivity Disorder (ADHD) Current protocols in protein science. ,vol. 54, ,(2011) , 10.1002/0471142301.NS0935S54
Mark A Stein, Thomas A Blondis, Eugene R Schnitzler, Tara O'Brien, Julie Fishkin, Brad Blackwell, Emily Szumowski, Nancy J Roizen, None, Methylphenidate Dosing: Twice Daily Versus Three Times Daily Pediatrics. ,vol. 98, pp. 748- 756 ,(1996)
V. Tropepe, H. L. Sive, Can zebrafish be used as a model to study the neurodevelopmental causes of autism Genes, Brain and Behavior. ,vol. 2, pp. 268- 281 ,(2003) , 10.1034/J.1601-183X.2003.00038.X
L. L. Field, K. Shumansky, J. Ryan, D. Truong, E. Swiergala, B. J. Kaplan, Dense-map genome scan for dyslexia supports loci at 4q13, 16p12, 17q22; suggests novel locus at 7q36. Genes, Brain and Behavior. ,vol. 12, pp. 56- 69 ,(2013) , 10.1111/GBB.12003
Julie M. Zito, Daniel J. Safer, Eric M. Fine, Increased methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics. ,vol. 98, pp. 1084- 1088 ,(1996)