Spinal dI2 interneurons regulate the stability of bipedal stepping
作者： Baruch Haimson , Yoav Hadas , Artur Kania , Monica Daley , Yuval Cinnamon
DOI: 10.1101/2020.01.07.898072
关键词:
摘要: Peripheral and intraspinal feedback is required to shape update the output of spinal networks that execute motor behavior. We report lumbar dI2 interneurons chick receive synaptic input from afferents pre-motoneurons. They innervate contralateral premotor in brachial cord their ascending projections cerebellum. These findings suggest neurons function as local circuits involved lumbo-brachial coupling part them deliver peripheral Silencing leads destabilized stepping P8 hatchlings with occasional collapses, variable step-profiles wide-base walking, suggesting may contribute stabilization bipedal gait.
sci-hub.st 参考文章(33)
Anna Griener, Wei Zhang, Henry Kao, Christine Wagner, Simon Gosgnach, Probing diversity within subpopulations of locomotor‐related V0 interneurons Developmental Neurobiology. ,vol. 75, pp. 1189- 1203 ,(2015) , 10.1002/DNEU.22277
Juan Jiang, Eiman Azim, Carl-Fredrik Ekerot, Bror Alstermark, Direct and indirect spino-cerebellar pathways: shared ideas but different functions in motor control. Frontiers in Computational Neuroscience. ,vol. 9, pp. 75- 75 ,(2015) , 10.3389/FNCOM.2015.00075
Katinka Stecina, Brent Fedirchuk, Hans Hultborn, Information to cerebellum on spinal motor networks mediated by the dorsal spinocerebellar tract The Journal of Physiology. ,vol. 591, pp. 5433- 5443 ,(2013) , 10.1113/JPHYSIOL.2012.249110
Y. Morikawa, T. Hisaoka, E. Senba, Characterization of Foxp2-expressing cells in the developing spinal cord. Neuroscience. ,vol. 162, pp. 1150- 1162 ,(2009) , 10.1016/J.NEUROSCIENCE.2009.05.022
J.I. Valenzuela, S.J. Hasan, J.D. Steeves, Stimulation of the brainstem reticular formation evokes locomotor activity in embryonic chicken (in ovo) Developmental Brain Research. ,vol. 56, pp. 13- 18 ,(1990) , 10.1016/0165-3806(90)90158-U
Nessan A. Bermingham, Bassem A. Hassan, Vincent Y. Wang, Michael Fernandez, Sandro Banfi, Hugo J. Bellen, Bernd Fritzsch, Huda Y. Zoghbi, Proprioceptor pathway development is dependent on Math1. Neuron. ,vol. 30, pp. 411- 422 ,(2001) , 10.1016/S0896-6273(01)00305-1
H. Bras, P. Cavallari, E. Jankowska, Demonstration of initial axon collaterals of cells of origin of the ventral spinocerebellar tract in the cat. The Journal of Comparative Neurology. ,vol. 273, pp. 584- 592 ,(1988) , 10.1002/CNE.902730412
Masato Furue, Shinsuke Uchida, Aya Shinozaki, Tomohiro Imagawa, Yoshinao Z. Hosaka, Masato Uehara, Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord Brain Behavior and Evolution. ,vol. 76, pp. 271- 278 ,(2010) , 10.1159/000321910
Charles W. Dunnett, A Multiple Comparison Procedure for Comparing Several Treatments with a Control Journal of the American Statistical Association. ,vol. 50, pp. 1096- 1121 ,(1955) , 10.1080/01621459.1955.10501294
Tuan V Bui, Turgay Akay, Osama Loubani, Thomas S Hnasko, Thomas M Jessell, Robert M Brownstone, Circuits for Grasping: Spinal dI3 Interneurons Mediate Cutaneous Control of Motor Behavior Neuron. ,vol. 78, pp. 191- 204 ,(2013) , 10.1016/J.NEURON.2013.02.007