Immunohistochemical study of α2 Macroglobulin receptor in Alzheimer and control postmortem human brain
作者： I. Tooyama , T. Kawamata , H. Akiyama , S. K. Moestrup , J. Gliemann
DOI: 10.1007/BF03160029
关键词:
摘要: Localization of the α2 macroglobulin receptor (α2MR) was studied in postmortem human brain tissue Alzheimer disease (AD) and age-matched control cases with a monoclonal antibody (A2MRα2) to receptor. In α2MR detected neurons, glia, some capillaries. Neuronal staining most conspicuous hippocampus entorhinal cortex. AD, immunoreactivity enhanced. The intensity neurons increased, as number positive glial cells. addition, senile plaques, tangles, dystrophic neurites were strongly stained. These results suggest that is involved AD pathology.
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D K Strickland, J D Ashcom, S Williams, W H Burgess, M Migliorini, W S Argraves, Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. Journal of Biological Chemistry. ,vol. 265, pp. 17401- 17404 ,(1990) , 10.1016/S0021-9258(18)38172-9
D.K. Striekland, J.D. Ashcom, S. Williams, F. Battey, E. Behre, K. McTigue, J.F. Battey, W.S. Argraves, Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. Journal of Biological Chemistry. ,vol. 266, pp. 13364- 13369 ,(1991) , 10.1016/S0021-9258(18)98848-4
L Sottrup-Jensen, Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. Journal of Biological Chemistry. ,vol. 264, pp. 11539- 11542 ,(1989) , 10.1016/S0021-9258(18)80094-1
S.K. Moestrup, J. Gliemann, Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors. Journal of Biological Chemistry. ,vol. 266, pp. 14011- 14017 ,(1991) , 10.1016/S0021-9258(18)92803-6
Alan J. Barrett, Phyllis M. Starkey, The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism Biochemical Journal. ,vol. 133, pp. 709- 724 ,(1973) , 10.1042/BJ1330709
P.H. Jensen, S.K. Moestrup, J. Gliemann, Purification of the human placental α2
-macroglobulin receptor FEBS Letters. ,vol. 255, pp. 275- 280 ,(1989) , 10.1016/0014-5793(89)81105-6
P.L. McGeer, T. Kawamata, D.G. Walker, Distribution of clusterin in Alzheimer brain tissue Brain Research. ,vol. 579, pp. 337- 341 ,(1992) , 10.1016/0006-8993(92)90071-G
Joachim Bauer, Sylvia Strauss, Ursula Schreiter-Gasser, Ursula Ganter, Petra Schlegel, Irene Witt, Benedikt Yolk, Mathias Berger, Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices FEBS Letters. ,vol. 285, pp. 111- 114 ,(1991) , 10.1016/0014-5793(91)80737-N
P.L. McGeer, H. Akiyama, S. Itagaki, E.G. McGeer, Activation of the classical complement pathway in brain tissue of Alzheimer patients Neuroscience Letters. ,vol. 107, pp. 341- 346 ,(1989) , 10.1016/0304-3940(89)90843-4
Torsten Kristensen, Søren K. Moestrup, Jørgen Gliemann, Lone Bendtsen, Ole Sand, Lars Sottrup-Jensen, Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the α2
-macroglobulin receptor FEBS Letters. ,vol. 276, pp. 151- 155 ,(1990) , 10.1016/0014-5793(90)80530-V