Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients.

作者: Boris Považay , Boris Hermann , Angelika Unterhuber , Bernd Hofer , Harald Sattmann

DOI: 10.1117/1.2773728

关键词:

摘要: Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of pathologies with greater penetration into choroidal tissue is compared to conventional 800 three-dimensional (3-D) ophthalmic FD-OCT systems. Furthermore, lower scattering at this significantly improves performance cataract patients, thereby widening clinical applicability OCT. The two spectrometer-based 3-D OCT systems respect their performance, one 150 bandwidth (approximately 3 microm effective axial resolution) and other 70 7 resolution). Results achieved reveal, first time, decisive improvements image quality patients clinically significant cataract.

参考文章(32)
Jun Zhang, Qiang Wang, Bin Rao, Zhongping Chen, Kevin Hsu, Swept laser source at 1μm for Fourier domain optical coherence tomography Applied Physics Letters. ,vol. 89, pp. 073901- ,(2006) , 10.1063/1.2335405
Juan Grunwald, Gerard Lutty, Masanobu Uyama, Shin Yoneya, Ajit B. Majji, Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Molecular Vision. ,vol. 5, pp. 35- ,(1999)
Wolfgang Drexler, Uwe Morgner, Ravi K. Ghanta, Franz X. Kärtner, Joel S. Schuman, James G. Fujimoto, Ultrahigh-resolution ophthalmic optical coherence tomography Nature Medicine. ,vol. 7, pp. 502- 507 ,(2001) , 10.1038/86589
Maciej Wojtkowski, Vivek J. Srinivasan, Tony H. Ko, James G. Fujimoto, Andrzej Kowalczyk, Jay S. Duker, Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Optics Express. ,vol. 12, pp. 2404- 2422 ,(2004) , 10.1364/OPEX.12.002404
R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, A. F. Fercher, Ultrahigh resolution Fourier domain optical coherence tomography Optics Express. ,vol. 12, pp. 2156- 2165 ,(2004) , 10.1364/OPEX.12.002156
F. Memarzadeh, Y. Li, B. A Francis, R. E Smith, J. Gutmark, D. Huang, Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty British Journal of Ophthalmology. ,vol. 91, pp. 189- 192 ,(2007) , 10.1136/BJO.2006.100099
R. Leitgeb, C. Hitzenberger, Adolf Fercher, Performance of fourier domain vs. time domain optical coherence tomography. Optics Express. ,vol. 11, pp. 889- 894 ,(2003) , 10.1364/OE.11.000889
Vivek J. Srinivasan, Maciej Wojtkowski, Andre J. Witkin, Jay S. Duker, Tony H. Ko, Mariana Carvalho, Joel S. Schuman, Andrzej Kowalczyk, James G. Fujimoto, High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography Ophthalmology. ,vol. 113, pp. 2054- 2065 ,(2006) , 10.1016/J.OPHTHA.2006.05.046
B. Povazay, K. Bizheva, B. Hermann, A. Unterhuber, H. Sattmann, A. Fercher, W. Drexler, C. Schubert, P. Ahnelt, M. Mei, R. Holzwarth, W. Wadsworth, J. Knight, P. St. J. Russell, Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050 nm Optics Express. ,vol. 11, pp. 1980- 1986 ,(2003) , 10.1364/OE.11.001980
A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, W. Drexler, In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid. Optics Express. ,vol. 13, pp. 3252- 3258 ,(2005) , 10.1364/OPEX.13.003252