Involvement of the endocannabinoid system in osteoarthritis pain.

摘要: Osteoarthritis is a degenerative joint disease associated with articular cartilage degradation. The major clinical outcome of osteoarthritis complex pain state that includes both nociceptive and neuropathic mechanisms. Currently, the therapeutic approaches for are limited as no drugs available to control progression analgesic treatment has restricted efficacy. Increasing evidence from preclinical studies supports interest endocannabinoid system an emerging target pain. Indeed, pharmacological have shown anti-nociceptive effects cannabinoids in different rodent models osteoarthritis, compelling suggests active participation pathophysiology this disease. ubiquitous distribution cannabinoid receptors, together physiological role regulation pain, inflammation even function further support osteoarthritis. However, been provided use cannabinoids, despite promising data. This review summarizes results recently obtained value management.