Beyond the stomach: An updated view ofHelicobacter pyloripathogenesis, diagnosis, and treatment

摘要: Helicobacter pylori (H. pylori) is an extremely common, yet underappreciated, pathogen that able to alter host physiology and subvert the immune response, allowing it persist for life of host. H. primary cause peptic ulcers gastric cancer. In United States, annual cost associated with ulcer disease estimated be $6 billion cancer kills over 700000 people per year globally. The prevalence infection remains high (> 50%) in much world, although rates are dropping some developed nations. drop could a double-edged sword, reducing incidence diseases while increasing risk allergies esophageal diseases. list potentially caused by continues grow; however, mechanistic explanations how contribute extragastric lag far behind clinical studies. A number factors virulence act concert determine which individuals at highest disease. These include bacterial cytotoxins polymorphisms genes responsible directing response. This review discusses latest advances pathogenesis, diagnosis, treatment. Up-to-date information on correlations between also provided.