Optical Doppler tomography and spectral Doppler imaging of localized ischemic stroke in a mouse model

摘要: We present a combined optical Doppler tomography/spectral imaging modality to quantitatively evaluate the dynamic blood circulation and the artery blockage before after localized ischemic stroke in mouse model. Optical Doppler Tomography (ODT) combines principle with coherence tomography for noninvasive localization measurement of particle flow velocity highly scattering media micrometer scale spatial resolution. Spectral (SDI) provides complementary temporal information spatially distributed imaging. Fast, repeated, ODT scans across an entire vessel were performed to record dynamic high resolution cardiac cycles. analysis of continuous images demonstrates how components longitudinally projected flow-volume-rate change over time scatters within volume using spectral waveforms. Furthermore, vascular conditions can be quantified various Doppler-angle-independent indices. Non-invasive in-vivo mice experiments microvascular