The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia

摘要: Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting diseases that can be fatal because of lung failure systemic cytokine storm. The development coronavirus-evoked pneumonia is associated with excessive inflammatory responses in the lung, known as "cytokine storms," which results pulmonary edema, atelectasis, acute injury (ALI) or respiratory distress syndrome (ARDS). No drugs are available to suppress overly immune response-mediated effectively. In light low toxicity its antioxidant, anti-inflammatory, antiviral activity, it plausible speculate curcumin could used a therapeutic drug for viral ALI/ARDS. Therefore, this review, we summarize mounting evidence obtained from preclinical studies using animal models lethal where exerts protective effects by regulating expression both pro- anti-inflammatory factors such IL-6, IL-8, IL-10, COX-2, promoting apoptosis PMN cells, scavenging reactive oxygen species (ROS), exacerbates response. These provide rationale agent against ALI/ARDS humans resulting coronaviral infection.