Active screening of group B streptococci with reduced penicillin susceptibility and altered serotype distribution isolated from pregnant women in Kobe, Japan.

摘要: Group B streptococcus (GBS; Streptococcus agalactiae) is a leading cause of neonatal invasive infections and was believed to be fully susceptible penicillin. However, we recently identified several clinical GBS isolates with reduced penicillin susceptibility (PRGBS), which were mainly isolated from respiratory specimens elderly people. An investigation both the isolation rate PRGBS serotype distribution among pregnant women crucial decisions regarding optimal prevention strategies for treatment in neonates. We collected 141 vaginal 122 hospital Kobe, Japan, 2007 2008. Of isolates, 139 subjected antimicrobial testing based on results screening by disk diffusion method. All G, ampicillin, cefotaxime, cefepime, meropenem; no detected. rates erythromycin clindamycin resistance 10.1% 5.0%, respectively, are much higher than values previously reported Japan. Serotypes VI VIII accounted 26% GBS; markedly decreased percentage observed around year 2000. These findings suggested that remains an effective means intrapartum antibiotic prophylaxis