Sulfuric acid esters of sugar alcohols

作者: Hans Peter Marki , Thomas Tschopp , Jurgen Fingerle , Hans Peter Wessel , Alexander Chucholowski

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摘要: The present invention is concerned with novel sulphuric acid esters of sugar alcohols and alcohol-like compounds the general formula. (I) wherein A residue a alcohol or derivative thereof devoid 1-hydroxy group, tris-(hydroxymethyl)methyl residue, at least one hydroxy group being esterified acid; X -NR1CO-; -NHCONH-; -NHCSNH-; -NHSO2-; -NR1- -O-; m p are each independently 0 1; R1 hydrogen, lower-alkyl hydroxy-lower-alkyl; B system conjugated multiple bonds; salts thereof. Furthermore, pharma-ceutical preparations containing compound formula 1 salt thereof; use their as medicaments, especially for treatment and/or prophylaxis arteriosclerotic changes in vascular wall, e.g. prevention restenosis after coronary peri-pheral angioplasty bypass operations; production medicaments said indications; well process manufacture salts.

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