De Novo and Acquired Resistance to Antitumor Alkylating Agents

摘要: Delineating mechanisms that mediate de novo and acquired resistance to alkylating agents could potentially lead novel targets for improving the efficacy of this important class anticancer drugs. De is likely contribute minimal residual disease subsequent emergence a more permanent form drug referred as resistance. The tumor microenvironment represents rich source both soluble factors components extracellular matrixes, which can favor cell survival following exposure. Experimental evidence suggests signals originate from are thereby facilitate DNA repair pathways, cycle checkpoints, metabolism, transporters, alterations in apoptotic machinery represent potential agents. role these pathways conferring will be discussed detail chapter.