Antioxidant activity of 3,4,5-trihydroxyphenylacetamide derivatives

摘要: A series of amide derivatives 3,4,5-trihydroxyphenylacetic acid was synthesized in two steps. The antioxidant activities were evaluated by using four different vitro models such as ABTS and DPPH radical scavenging activity FTC TBA anti-lipid peroxidation activity. Most compounds more powerful scavengers than vitamin C comparable to Trolox. It found that there no direct correlations between anti-peroxidation activities. inhibitory compound on lipid showed remarkable dependency both the number phenolic hydroxyl group length methylene linker N-arylalkyl amide. Compound 14, a conjugate dopamine, propyl gallate all assays. synthesized.